Dr. David Shackelford, UCLA Jonsson Comprehensive Cancer Center member and assistant professor of pulmonary and critical care medicine at UCLA, has been awarded a Research Career Development Award of $150,000 over three years by STOP CANCER to further advance his research into how lung cancer tumor cell vulnerabilities may be harnessed to develop new and more effective therapies.
STOP CANCER, a nonprofit volunteer organization based in Los Angeles, funds promising and innovative scientists conducting research on all forms of cancer. With a primary focus on beginning investigators, this career development award seeks to facilitate major cancer achievements and elevate and expose young researchers to opportunities for growth, discovery and collaboration.
Lung cancer is the leading cause of cancer deaths worldwide, and the American Lung Association estimates more than 158,000 people in the United States will die from the disease this year alone.
Preliminary work in Shackelford’s lab investigated how alterations in signal transduction pathways in lung cancer lead to unregulated metabolism and increased cellular stress that create vulnerabilities in tumor cells. By studying the roles metabolism and stress play in tumor cell development, researchers aim to identify how these vulnerabilities can be exploited to develop innovative cancer therapies.
The three-year grant will allow Shackelford’s team to also examine the potential of repurposing existing drugs, such as biguanides (which have historically been used to treat diabetes) for use as anti-cancer agents.