Science + Technology

Foxes on one of California’s Channel Islands have least genetic variation of all wild animals

UCLA biologists write that findings should help guide how endangered species are treated

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A Channel Island fox
Lyndal Laughrin

Some subspecies of Channel Island foxes could be removed from federal endangered species protection.

UCLA biologists report in a new study that a species of foxes living on six of California’s Channel Islands have a surprising absence of genetic variation. The research, published today in the Cell Press journal Current Biology, provides a complete genome sequence for a small population of the endangered animals, which have been confined to the islands for thousands of years.

The researchers write that their work could help guide future long-term conservation efforts for small, endangered populations.

The Channel Island foxes are dwarves, two-thirds the size of their mainland relatives. They most likely evolved from gray foxes that were brought to the northern islands by humans more than 7,000 years ago. A group on one of the islands in particular, San Nicolas Island, has nearly an order of magnitude less genetic variation than any other low-diversity species, including the severely endangered African cheetah, Mountain gorilla, and Tasmanian devil.

That finding, which was established by earlier research, does not bode well for the foxes, said Jacqueline Robinson, the study’s lead author, a UCLA graduate student in ecology and evolutionary biology. A lack of genetic diversity means that individuals within a population are all equally susceptible to disease, and that the species might not be able to respond to a changing environment, she said.

“The island fox populations suffer from both a lack of genetic diversity and the accumulation of damaging genetic variants, which are likely to worsen over time,” said Robert Wayne, a professor of ecology and evolutionary biology in the UCLA College. “Our findings emphasize the importance of large population size in order to allow natural selection to operate effectively. It is imperative that we do not let species come to the very brink of extinction, when there are only a handful of individuals remaining, before we intervene to increase their numbers.”

Specifically, government agencies should extend endangered species protection before a species’ population reaches critically low numbers, when negative genetic consequences become highly likely.

The research also raised a question that the researchers haven’t yet been able to answer: How have the foxes managed to survive as well as they have?

“The degree to which the San Nicolas foxes have lost genetic variation is remarkable,” Wayne said. “It suggests that under some conditions, genetic variation is not absolutely essential for the persistence of endangered populations.”

For example, Robinson said, unlike other species with low diversity, island foxes have not yet been found to suffer from severe signs of inbreeding depression.

The researchers compared DNA samples collected in 1988 from each of the Channel Island fox populations with one from a gray fox from mainland Southern California.

Biological theory holds that small populations of animals will lose their genetic variation, and will accumulate harmful mutations as the normal process of natural selection fails. The UCLA study found that both were true of the island foxes’ genomes.

The researchers write that their new findings should be considered in plans for the foxes’ future, including the possible delisting from endangered species protection for some of their subspecies — a proposal that is currently being considered by the U.S. Fish and Wildlife Service.

The study was funded by a postdoctoral fellowship at the UCLA Institute for Quantitative and Computational Biosciences Collaboratory; the QCB Collaboratory community; a University of California President’s Research Catalyst Award; a Searle Scholars fellowship; and an Alfred P. Sloan research fellowship.

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