UCLA researchers’ findings could work against a broad range of viruses and protect against Zika and its associated neurological defects in mice and human brain models.
UCLA researchers found that a combination therapy going after stem cells and chemotherapy resulted in better outcomes.
The new protocol opens the door to researchers who want to make muscle, bone and cartilage cells in the lab; the scientists plan to study whether the method could be help treat Duchenne muscular dystrophy.
Researchers have demonstrated how specialized proteins are able to change the cellular characteristics of skin cells and create induced pluripotent stem cells, which have the ability to turn into any cell type in the body. The findings could influence the creation of healthy tissues to cure disease.
To turn on its genome — the full set of genes inherited from each parent — a mammalian embryo needs to relocate a group of proteins, researchers have discovered. The metabolic proteins move to the DNA-containing nuclei about two days after a mouse embryo is fertilized, according to the study.
The team found a way to correct the instability by resetting the stem cells from a later stage of development to an earlier stage. These results could have great impact on the creation of healthy tissues to cure disease.
The findings could one day lead to improved therapies for people undergoing chemotherapy and radiation treatment for cancer.
UCLA scientists have found that calcification of heart muscle tissue is caused when a type of cell called cardiac fibroblasts go awry.
The laboratory-grown tissue can be used to study diseases including idiopathic pulmonary fibrosis, which has traditionally been difficult to study using conventional methods.
The least developed human embryonic stem cells, or “naïve” pluripotent stem cells, consume more sugar than “primed” pluripotent stem cells, which are embryonic stem cells from later in development, researchers have discovered.
A team of scientists including researchers from UCLA has developed an RNA sequencing technique that could advance scientists’ use of stem cells in regenerative medicine.
Scientists at the UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have discovered that a certain metabolic molecule helps pluripotent stem cells mature faster.
The two-year, $2.15 million grant from the California Institute for Regenerative Medicine will fund research by April Pyle, Melissa Spencer and Huan Meng.
Because of the pioneering work of Dr. Donald Kohn, a researcher with UCLA's Broad Stem Cell Research Center, the potential to bring stem cell therapies to patients is now a reality.
Witte’s accomplishments include impactful scientific discoveries, advocacy for science education funding and exemplary leadership.
UCLA researchers pinpointed the function of a cluster of specialized genes that play a key role in creating and preserving hematopoietic stem cells and identified the process by which those genes are activated.
The researchers found that an experimental drug called CD532, which changes the structure of a key protein, reduced the size of tumors in mice by 80 percent.
Funding from the California Institute for Regenerative Medicine will support work to genetically engineer immune cells to fight cancer.
Discovery is an important step in the effort to better understand and treat aggressive childhood leukemia.
The study was the first to create corrected human iPS cells that could directly restore functional muscle tissue affected by the disease.
Discovery provides scientists with critical information on the best way to create stem cells for purposes such as cell transplantation or organ regeneration.
The research is a significant step forward in the use of human embryonic stem cells for heart regeneration.
The discovery could point the way toward new drugs that slow or stop the disease from spreading.
Using Broad Stem Cell Research Center’s cell isolation and genetic sequencing technologies and sophisticated bioinformatics, scientists identify elusive LncRNA genes.
Researchers say this research gives important insight into the cellular nature of aggressive prostate cancer, which will aid in the development of better treatments.