The study, conducted in mice, is the first to show that creatine uptake is critical to the anti-tumor activities of what is known as killer T cells, the foot soldiers of the immune system.
Arginase deficiency, which is caused by a missing or mutated version of the arginase gene, ARG1, affects about one of every 1 million babies in the U.S.
Research brief: A gene on the X-chromosome may help explain why more women than men develop autoimmune diseases, including multiple sclerosis.
A Finnish study that included researchers from UCLA harnessed the DNA from nearly 20,000 people to identify genetic mutations that may increase the risk of diabetes, high cholesterol and other diseases and conditions.
The discoveries by an interdisciplinary team of UCLA scientists could improve the diagnoses of these aggressive cancers.
The findings have implications for the conservation of rare and endangered species, in which low genetic diversity could increase the odds of extinction.
UCLA researchers launch open-source software that can identify a broad range of species from samples.
The findings will both help identify women who are at highest risk of developing ovarian cancer and pave the way for identifying new therapies that can target these specific genes.
The UCLA-led group has created an online resource guide to help scientists in lower-income countries jumpstart research programs.
“This is a pervasive, global problem.... It’s in all types of landscapes — urban, rural and even untouched environments,” says Seth Riley, a co-author of the research.
The study suggests that silencing, or blocking the expression of a particular protein by using a patented technology may offer a new treatment.
Changes in RNA editing play an important role in the disorder, scientists find.
UCLA’s Dr. Michael Gandal said that beyond the important new findings, he is even more optimistic about what the data will help researchers learn in the future.
The study is the most comprehensive published effort to date to identify the source of neurodegeneration across species.
The life scientists have provided the first cell “atlas” of the hippocampus — the part of the brain that helps regulate learning and memory — when it is affected by traumatic brain injury.
The Los Angeles Seafood Monitoring Project is seeking to reduce sushi fraud and the mislabeling of fish.
Although the study analyzed information dating back to the mid-19th century, the findings could have important implications for human health today.
The genetic technique is a step toward a strategy to help people with autism better process visual information.
The study could lead to new treatments for a range of advanced epithelial cancers such as lung, prostate and bladder cancers.
The findings may eventually lead to researchers discovering a new way to control the proteins found at synapses and, in turn, treat diseases characterized by synaptic dysfunction.
The bioinformatics approach the team used to uncover the weed killer could potentially be used to find new drugs for antibacterial medicines.
The next step is to determine why the numbers are so low and find ways to increase those rates of testing.
An increase in the number and severity of heat waves over the coming years would pose a particular challenge for the species because small-bodied birds dehydrate more quickly.
Researchers led by UCLA’s Dr. Paul Krebsbach are the first to characterize the mechanism of the gene, and they found it regulates the molecular process that dictates cell growth and human development.
The discovery by UCLA geneticists could lead to new drugs to treat diabetes, obesity and heart disease.