A drug that suppresses the gene could lead to the first pill to treat stroke’s aftermath.
The findings could pave the way for new treatments for heart valve disorders, which can be caused by congenital defects, aging or disease.
A technique they developed coaxes pluripotent stem cells — which can can be grown indefinitely in the lab — into becoming mature T cells capable of killing tumor cells.
The condition, which affects red blood cells’ ability to produce regulatory T cells, can affect the intestines, pancreas and thyroid, as well as other parts of the body.
The findings could lead to a better understanding of the metabolic needs of many different types of cancer.
Previous research hinted that small cell cancers from different organs may be driven by common mechanisms, but the new study is the first to so clearly describe the steps in their evolution.
The study could lead to new treatments for a range of advanced epithelial cancers such as lung, prostate and bladder cancers.
The results could have implications for treating cancer, when people’s blood-forming stem cells may be depleted, and for people undergoing transplant surgery.
The findings could lead to new methods to help prevent clots and repair damage that can result from the placement of stents.
The findings open up possibilities for new therapies to treat such conditions as osteoporosis and skeletal aging.
The study, led by Professor Amander Clark, could lead to important advances in an area of medicine that historically has been underfunded and underappreciated.
Nanostructures created by UCLA scientists could make gene therapies safer, faster and more affordable
The new method uses 'nanospears' to deliver genes directly to patient cells. Gene therapy has shown great promise as a treatment for a host of diseases, including hemophilia and certain types of cancer.
“Our ultimate goal is to be able to regenerate cardiomyocytes after an injury like a heart attack,” Dr. Reza Ardehali said. “But we’re first trying to learn from the embryonic heart.”
The techniques the researchers employed should pave the way to additional studies on the tumors’ molecular details.
A new study suggests that cells engineered by a UCLA-led team have the potential to provide long-term immunity against the virus that causes AIDS.
Boosting cholesterol levels in mice spurs their intestinal stem cells to divide faster, dramatically speeding the formation of tumors.
The protocol could be a step toward therapies to restore sensation in people who are paralyzed and have lost feeling in parts of their body.
The process could help restore dystrophin, the protein missing in the muscles of boys with Duchenne muscular dystrophy.
UCLA researchers discovered that, when heart muscle cells were mixed with high levels of glucose, they matured late or failed to mature altogether, and instead generated more immature cells.
Using the organoids they created, researchers were able to identify drugs that could prevent the virus’s damaging effects.
The research may lead to new drugs that could promote hair growth for people with baldness or alopecia, which is hair loss linked to such factors such as hormonal imbalance, stress, aging or chemotherapy.
UCLA study identifies a potential test that may help select patients for whom it could be most effective.
The findings by UCLA researchers could help scientists replicate or control the way axons grow, which could be applicable for diseases that affect the nervous system.
Researchers from the Broad Stem Cell Research Center created a system to produce human T cells, the white blood cells that fight against disease-causing intruders in the body.
Adenosine deaminase-deficient severe combined immunodeficiency is a rare and life-threatening condition that can be fatal within the first year of life if left untreated.