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UCLA research reveals key difference in how stem cells act when stressed versus when at rest
The results could have implications for treating cancer, when people’s blood-forming stem cells may be depleted, and for people undergoing transplant surgery.
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UCLA researchers discover how the body regenerates blood vessel lining
The findings could lead to new methods to help prevent clots and repair damage that can result from the placement of stents.
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UCLA researchers discover gene that controls bone-to-fat ratio in bone marrow
The findings open up possibilities for new therapies to treat such conditions as osteoporosis and skeletal aging.
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UCLA research may explain some causes of infertility and miscarriage
The study, led by Professor Amander Clark, could lead to important advances in an area of medicine that historically has been underfunded and underappreciated.
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Nanostructures created by UCLA scientists could make gene therapies safer, faster and more affordable
The new method uses 'nanospears' to deliver genes directly to patient cells. Gene therapy has shown great promise as a treatment for a host of diseases, including hemophilia and certain types of cancer.
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UCLA scientists use color-coded tags to discover how heart cells develop
“Our ultimate goal is to be able to regenerate cardiomyocytes after an injury like a heart attack,” Dr. Reza Ardehali said. “But we’re first trying to learn from the embryonic heart.”
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UCLA scientists use stem cells to study genetics of germ cell tumors
The techniques the researchers employed should pave the way to additional studies on the tumors’ molecular details.
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Gene therapy using CAR T cells could provide long-term protection against HIV
A new study suggests that cells engineered by a UCLA-led team have the potential to provide long-term immunity against the virus that causes AIDS.
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UCLA study could explain link between high-cholesterol diet and colon cancer
Boosting cholesterol levels in mice spurs their intestinal stem cells to divide faster, dramatically speeding the formation of tumors.
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UCLA scientists make cells that enable the sense of touch
The protocol could be a step toward therapies to restore sensation in people who are paralyzed and have lost feeling in parts of their body.
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UCLA researchers create skeletal muscle from stem cells
The process could help restore dystrophin, the protein missing in the muscles of boys with Duchenne muscular dystrophy.
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Research reveals how diabetes in pregnancy affects baby’s heart
UCLA researchers discovered that, when heart muscle cells were mixed with high levels of glucose, they matured late or failed to mature altogether, and instead generated more immature cells.
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Better ‘mini brains’ could help scientists identify treatments for Zika-related brain damage
Using the organoids they created, researchers were able to identify drugs that could prevent the virus’s damaging effects.
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UCLA scientists identify a new way to activate stem cells to make hair grow
The research may lead to new drugs that could promote hair growth for people with baldness or alopecia, which is hair loss linked to such factors such as hormonal imbalance, stress, aging or chemotherapy.
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Combination therapy could provide new treatment option for ovarian cancer
UCLA study identifies a potential test that may help select patients for whom it could be most effective.
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Study overturns seminal research about the developing nervous system
The findings by UCLA researchers could help scientists replicate or control the way axons grow, which could be applicable for diseases that affect the nervous system.
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Artificial thymus developed at UCLA can produce cancer-fighting T cells from blood stem cells
Researchers from the Broad Stem Cell Research Center created a system to produce human T cells, the white blood cells that fight against disease-causing intruders in the body.
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Pioneering stem cell gene therapy cures infants with bubble baby disease
Adenosine deaminase-deficient severe combined immunodeficiency is a rare and life-threatening condition that can be fatal within the first year of life if left untreated.
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Natural compound protects against Zika virus infection and microcephaly
UCLA researchers’ findings could work against a broad range of viruses and protect against Zika and its associated neurological defects in mice and human brain models.
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Targeting cancer stem cells improves treatment effectiveness and prevents metastasis
UCLA researchers found that a combination therapy going after stem cells and chemotherapy resulted in better outcomes.
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UCLA researchers turn stem cells into somites, precursors to skeletal muscle, cartilage and bone
The new protocol opens the door to researchers who want to make muscle, bone and cartilage cells in the lab; the scientists plan to study whether the method could be help treat Duchenne muscular dystrophy.
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Study pinpoints how skin cells’ identity can be disassembled to create stem cells
Researchers have demonstrated how specialized proteins are able to change the cellular characteristics of skin cells and create induced pluripotent stem cells, which have the ability to turn into any cell type in the body. The findings could influence the creation of healthy tissues to cure disease.
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Metabolic proteins relocate to jump-start an embryo’s genome, UCLA study finds
To turn on its genome — the full set of genes inherited from each parent — a mammalian embryo needs to relocate a group of proteins, researchers have discovered. The metabolic proteins move to the DNA-containing nuclei about two days after a mouse embryo is fertilized, according to the study.
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Researchers discover method to stabilize X chromosomes in human embryonic stem cells
The team found a way to correct the instability by resetting the stem cells from a later stage of development to an earlier stage. These results could have great impact on the creation of healthy tissues to cure disease.
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Genetic factors control regenerative properties of blood-forming stem cells, UCLA studies show
The findings could one day lead to improved therapies for people undergoing chemotherapy and radiation treatment for cancer.
- Tuesday, August 14, 2018