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Better ‘mini brains’ could help scientists identify treatments for Zika-related brain damage
Using the organoids they created, researchers were able to identify drugs that could prevent the virus’s damaging effects.
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UCLA scientists identify a new way to activate stem cells to make hair grow
The research may lead to new drugs that could promote hair growth for people with baldness or alopecia, which is hair loss linked to such factors such as hormonal imbalance, stress, aging or chemotherapy.
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Combination therapy could provide new treatment option for ovarian cancer
UCLA study identifies a potential test that may help select patients for whom it could be most effective.
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Study overturns seminal research about the developing nervous system
The findings by UCLA researchers could help scientists replicate or control the way axons grow, which could be applicable for diseases that affect the nervous system.
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Artificial thymus developed at UCLA can produce cancer-fighting T cells from blood stem cells
Researchers from the Broad Stem Cell Research Center created a system to produce human T cells, the white blood cells that fight against disease-causing intruders in the body.
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Pioneering stem cell gene therapy cures infants with bubble baby disease
Adenosine deaminase-deficient severe combined immunodeficiency is a rare and life-threatening condition that can be fatal within the first year of life if left untreated.
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Natural compound protects against Zika virus infection and microcephaly
UCLA researchers’ findings could work against a broad range of viruses and protect against Zika and its associated neurological defects in mice and human brain models.
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Targeting cancer stem cells improves treatment effectiveness and prevents metastasis
UCLA researchers found that a combination therapy going after stem cells and chemotherapy resulted in better outcomes.
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UCLA researchers turn stem cells into somites, precursors to skeletal muscle, cartilage and bone
The new protocol opens the door to researchers who want to make muscle, bone and cartilage cells in the lab; the scientists plan to study whether the method could be help treat Duchenne muscular dystrophy.
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Study pinpoints how skin cells’ identity can be disassembled to create stem cells
Researchers have demonstrated how specialized proteins are able to change the cellular characteristics of skin cells and create induced pluripotent stem cells, which have the ability to turn into any cell type in the body. The findings could influence the creation of healthy tissues to cure disease.
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Metabolic proteins relocate to jump-start an embryo’s genome, UCLA study finds
To turn on its genome — the full set of genes inherited from each parent — a mammalian embryo needs to relocate a group of proteins, researchers have discovered. The metabolic proteins move to the DNA-containing nuclei about two days after a mouse embryo is fertilized, according to the study.
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Researchers discover method to stabilize X chromosomes in human embryonic stem cells
The team found a way to correct the instability by resetting the stem cells from a later stage of development to an earlier stage. These results could have great impact on the creation of healthy tissues to cure disease.
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Genetic factors control regenerative properties of blood-forming stem cells, UCLA studies show
The findings could one day lead to improved therapies for people undergoing chemotherapy and radiation treatment for cancer.
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Researchers discover how to prevent calcification of heart tissue
UCLA scientists have found that calcification of heart muscle tissue is caused when a type of cell called cardiac fibroblasts go awry.
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UCLA researchers use stem cells to grow 3-D lung-in-a-dish
The laboratory-grown tissue can be used to study diseases including idiopathic pulmonary fibrosis, which has traditionally been difficult to study using conventional methods.
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Less developed human stem cells are found to metabolize more sugar
The least developed human embryonic stem cells, or “naïve” pluripotent stem cells, consume more sugar than “primed” pluripotent stem cells, which are embryonic stem cells from later in development, researchers have discovered.
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Scientists develop new way to measure important chemical modification on RNA
A team of scientists including researchers from UCLA has developed an RNA sequencing technique that could advance scientists’ use of stem cells in regenerative medicine.
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Metabolic molecule speeds up process by which stem cells differentiate
Scientists at the UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have discovered that a certain metabolic molecule helps pluripotent stem cells mature faster.
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UCLA Duchenne muscular dystrophy research receives grant from California’s stem cell agency
The two-year, $2.15 million grant from the California Institute for Regenerative Medicine will fund research by April Pyle, Melissa Spencer and Huan Meng.
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Curing 'bubble baby' disease: From the lab to the clinic
Because of the pioneering work of Dr. Donald Kohn, a researcher with UCLA's Broad Stem Cell Research Center, the potential to bring stem cell therapies to patients is now a reality.
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UC regents appoint Dr. Owen Witte University Professor
Witte’s accomplishments include impactful scientific discoveries, advocacy for science education funding and exemplary leadership.
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Stem cell advance could be key step toward treating deadly blood diseases
UCLA researchers pinpointed the function of a cluster of specialized genes that play a key role in creating and preserving hematopoietic stem cells and identified the process by which those genes are activated.
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UCLA scientists pinpoint cancer gene responsible for neuroendocrine prostate cancer
The researchers found that an experimental drug called CD532, which changes the structure of a key protein, reduced the size of tumors in mice by 80 percent.
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UCLA stem cell researcher receives $7.6 million grant
Funding from the California Institute for Regenerative Medicine will support work to genetically engineer immune cells to fight cancer.
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Cellular protein plays important role in aggressive childhood cancer
Discovery is an important step in the effort to better understand and treat aggressive childhood leukemia.
- Friday, October 20, 2017