A technique they developed coaxes pluripotent stem cells — which can can be grown indefinitely in the lab — into becoming mature T cells capable of killing tumor cells.
The condition, which affects red blood cells’ ability to produce regulatory T cells, can affect the intestines, pancreas and thyroid, as well as other parts of the body.
Previous research hinted that small cell cancers from different organs may be driven by common mechanisms, but the new study is the first to so clearly describe the steps in their evolution.
The results could have implications for treating cancer, when people’s blood-forming stem cells may be depleted, and for people undergoing transplant surgery.
The study, led by Professor Amander Clark, could lead to important advances in an area of medicine that historically has been underfunded and underappreciated.
The new method uses 'nanospears' to deliver genes directly to patient cells. Gene therapy has shown great promise as a treatment for a host of diseases, including hemophilia and certain types of cancer.
“Our ultimate goal is to be able to regenerate cardiomyocytes after an injury like a heart attack,” Dr. Reza Ardehali said. “But we’re first trying to learn from the embryonic heart.”
UCLA researchers discovered that, when heart muscle cells were mixed with high levels of glucose, they matured late or failed to mature altogether, and instead generated more immature cells.
The research may lead to new drugs that could promote hair growth for people with baldness or alopecia, which is hair loss linked to such factors such as hormonal imbalance, stress, aging or chemotherapy.
The findings by UCLA researchers could help scientists replicate or control the way axons grow, which could be applicable for diseases that affect the nervous system.