The protocol could be a step toward therapies to restore sensation in people who are paralyzed and have lost feeling in parts of their body.
The process could help restore dystrophin, the protein missing in the muscles of boys with Duchenne muscular dystrophy.
UCLA researchers discovered that, when heart muscle cells were mixed with high levels of glucose, they matured late or failed to mature altogether, and instead generated more immature cells.
Using the organoids they created, researchers were able to identify drugs that could prevent the virus’s damaging effects.
The research may lead to new drugs that could promote hair growth for people with baldness or alopecia, which is hair loss linked to such factors such as hormonal imbalance, stress, aging or chemotherapy.
UCLA study identifies a potential test that may help select patients for whom it could be most effective.
The findings by UCLA researchers could help scientists replicate or control the way axons grow, which could be applicable for diseases that affect the nervous system.
Researchers from the Broad Stem Cell Research Center created a system to produce human T cells, the white blood cells that fight against disease-causing intruders in the body.
Adenosine deaminase-deficient severe combined immunodeficiency is a rare and life-threatening condition that can be fatal within the first year of life if left untreated.
UCLA researchers’ findings could work against a broad range of viruses and protect against Zika and its associated neurological defects in mice and human brain models.
UCLA researchers found that a combination therapy going after stem cells and chemotherapy resulted in better outcomes.
The new protocol opens the door to researchers who want to make muscle, bone and cartilage cells in the lab; the scientists plan to study whether the method could be help treat Duchenne muscular dystrophy.
Researchers have demonstrated how specialized proteins are able to change the cellular characteristics of skin cells and create induced pluripotent stem cells, which have the ability to turn into any cell type in the body. The findings could influence the creation of healthy tissues to cure disease.
To turn on its genome — the full set of genes inherited from each parent — a mammalian embryo needs to relocate a group of proteins, researchers have discovered. The metabolic proteins move to the DNA-containing nuclei about two days after a mouse embryo is fertilized, according to the study.
The team found a way to correct the instability by resetting the stem cells from a later stage of development to an earlier stage. These results could have great impact on the creation of healthy tissues to cure disease.
The findings could one day lead to improved therapies for people undergoing chemotherapy and radiation treatment for cancer.
UCLA scientists have found that calcification of heart muscle tissue is caused when a type of cell called cardiac fibroblasts go awry.
The laboratory-grown tissue can be used to study diseases including idiopathic pulmonary fibrosis, which has traditionally been difficult to study using conventional methods.
The least developed human embryonic stem cells, or “naïve” pluripotent stem cells, consume more sugar than “primed” pluripotent stem cells, which are embryonic stem cells from later in development, researchers have discovered.
A team of scientists including researchers from UCLA has developed an RNA sequencing technique that could advance scientists’ use of stem cells in regenerative medicine.
Scientists at the UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have discovered that a certain metabolic molecule helps pluripotent stem cells mature faster.
The two-year, $2.15 million grant from the California Institute for Regenerative Medicine will fund research by April Pyle, Melissa Spencer and Huan Meng.
Because of the pioneering work of Dr. Donald Kohn, a researcher with UCLA's Broad Stem Cell Research Center, the potential to bring stem cell therapies to patients is now a reality.
Witte’s accomplishments include impactful scientific discoveries, advocacy for science education funding and exemplary leadership.
UCLA researchers pinpointed the function of a cluster of specialized genes that play a key role in creating and preserving hematopoietic stem cells and identified the process by which those genes are activated.