The findings open up possibilities for new therapies to treat such conditions as osteoporosis and skeletal aging.
The study, led by Professor Amander Clark, could lead to important advances in an area of medicine that historically has been underfunded and underappreciated.
Nanostructures created by UCLA scientists could make gene therapies safer, faster and more affordable
The new method uses 'nanospears' to deliver genes directly to patient cells. Gene therapy has shown great promise as a treatment for a host of diseases, including hemophilia and certain types of cancer.
“Our ultimate goal is to be able to regenerate cardiomyocytes after an injury like a heart attack,” Dr. Reza Ardehali said. “But we’re first trying to learn from the embryonic heart.”
The techniques the researchers employed should pave the way to additional studies on the tumors’ molecular details.
A new study suggests that cells engineered by a UCLA-led team have the potential to provide long-term immunity against the virus that causes AIDS.
Boosting cholesterol levels in mice spurs their intestinal stem cells to divide faster, dramatically speeding the formation of tumors.
The protocol could be a step toward therapies to restore sensation in people who are paralyzed and have lost feeling in parts of their body.
The process could help restore dystrophin, the protein missing in the muscles of boys with Duchenne muscular dystrophy.
UCLA researchers discovered that, when heart muscle cells were mixed with high levels of glucose, they matured late or failed to mature altogether, and instead generated more immature cells.
Using the organoids they created, researchers were able to identify drugs that could prevent the virus’s damaging effects.
The research may lead to new drugs that could promote hair growth for people with baldness or alopecia, which is hair loss linked to such factors such as hormonal imbalance, stress, aging or chemotherapy.
UCLA study identifies a potential test that may help select patients for whom it could be most effective.
The findings by UCLA researchers could help scientists replicate or control the way axons grow, which could be applicable for diseases that affect the nervous system.
Researchers from the Broad Stem Cell Research Center created a system to produce human T cells, the white blood cells that fight against disease-causing intruders in the body.
Adenosine deaminase-deficient severe combined immunodeficiency is a rare and life-threatening condition that can be fatal within the first year of life if left untreated.
UCLA researchers’ findings could work against a broad range of viruses and protect against Zika and its associated neurological defects in mice and human brain models.
UCLA researchers found that a combination therapy going after stem cells and chemotherapy resulted in better outcomes.
The new protocol opens the door to researchers who want to make muscle, bone and cartilage cells in the lab; the scientists plan to study whether the method could be help treat Duchenne muscular dystrophy.
Researchers have demonstrated how specialized proteins are able to change the cellular characteristics of skin cells and create induced pluripotent stem cells, which have the ability to turn into any cell type in the body. The findings could influence the creation of healthy tissues to cure disease.
To turn on its genome — the full set of genes inherited from each parent — a mammalian embryo needs to relocate a group of proteins, researchers have discovered. The metabolic proteins move to the DNA-containing nuclei about two days after a mouse embryo is fertilized, according to the study.
The team found a way to correct the instability by resetting the stem cells from a later stage of development to an earlier stage. These results could have great impact on the creation of healthy tissues to cure disease.
The findings could one day lead to improved therapies for people undergoing chemotherapy and radiation treatment for cancer.
UCLA scientists have found that calcification of heart muscle tissue is caused when a type of cell called cardiac fibroblasts go awry.
The laboratory-grown tissue can be used to study diseases including idiopathic pulmonary fibrosis, which has traditionally been difficult to study using conventional methods.