When stem cells can’t roll on a bumpy road, muscles break down
A study in mice shows that scarring of collagen pathways prevent stem cells from healing damaged tissue in Duchenne muscular dystrophy.
stem cells
Results
CIRM grant will help expand patients’ access to UCLA clinical trials for stem cell, gene therapies
The funds will also support education programs and workforce development through the UCLA Alpha Stem Cell Clinic.
Making lab-grown brain organoids ‘brainier’
A UCLA-led team has discovered that using early-stage stem cells is a key to producing structures that are reliable models of disease.
Cell therapy could improve bone marrow transplant safety
A new study in mice suggests that adding iNKT cells to a stem cell transplant could reduce complication severity.
Scientists develop blueprint for turning stem cells into sensory interneurons
The research is an important advance toward cell therapies that could restore sensation in people with spinal cord injuries.
UCLA-led team creates first comprehensive map of human blood stem cell development
The study could eventually lead to more treatment options for leukemia, sickle cell disease and other conditions.
UCLA receives $5 million to help translate promising research from lab to clinic
A gift from the Alfred E. Mann Family Foundation will support research at the Broad Stem Cell Research Center and California NanoSystems Institute.
UCLA gene therapy gives new life to girl born with fatal immune disorder
After more than two years, Marley Gaskins, the first child to receive the innovative treatment for LAD-1, remains disease-free.
Q&A: Dr. Thomas Rando on preventing age-related diseases and turning discoveries into cures
Meet the new director of the UCLA Broad Stem Cell Research Center.
A longer-lasting COVID vaccine? UCLA study points the way
Research brief: Adding a protein called viral polymerase to vaccines could potentially create a more robust, enduring immune response, scientists say.
Researchers discover an unexpected regulator of heart repair
Research brief: A UCLA-led study identifies a potential target for therapies to prevent or treat heart failure.
UCLA scientists make strides toward an ‘off-the-shelf’ immune cell therapy for cancer
Using stem cell engineering and organoid technology, UCLA researchers were able to produce large quantities of powerful cancer-fighting iNKT cells.
Xist marks the spot: How an RNA molecule silences the X chromosome
UCLA researchers use super-resolution microscopy to reveal surprising new details about X inactivation in female mouse embryos.
A decade after gene therapy, children born with deadly immune disorder remain healthy
Researchers report that all nine patients who were successfully treated for ADA-SCID in a UCLA clinical trial from 2009 to 2012 are still disease-free.
$6.2 million NIH grant to support UCLA study of how COVID-19 causes multiple organ failure
“We need to figure out how this is happening in order to develop treatments to stop it,” said UCLA’s Arjun Deb.
UCLA Broad Stem Cell Research Center receives $5 million CIRM grant for research training program
The five-year award from California’s stem cell agency will help prepare young scientists and physicians to become leaders in the regenerative medicine field.
Scientists develop brain organoids with complex neural activity
A UCLA study suggests researchers could analyze neurological disorders in a stem cell–derived model.
Thomas Rando named director of UCLA Broad Stem Cell Research Center
The renowned neurologist and stem cell biologist is currently a professor at Stanford University.
Drug commonly used as antidepressant helps fight cancer in mice
UCLA researchers discover that MAOIs could activate immune system to shrink various types of tumors.
Gene therapy offers potential cure to children born without an immune system
The treatment, developed by researchers from UCLA and the U.K., has restored immune function in more than 95% of patients in three clinical trials.
Stem cell therapy promotes recovery from stroke and dementia in mice
A UCLA study identifies a cell therapy that can stop progressive damage and stimulate the brain’s repair processes in mice.
Researchers devise more efficient, enduring CAR gene therapy to combat HIV
Research brief: A UCLA team has demonstrated that altering a key molecule used in the therapy yields superior and longer-lasting results in mouse models.
UC group launches clinical trial using CRISPR to correct sickle cell disease gene defect
The project is the first to use the Nobel prize–winning technology to directly correct sickle mutation in blood stem cells.
Potential COVID-19 treatment identified in UCLA-led lab study
Professors Robert Damoiseaux and Vaithilingaraja Arumugaswami led a collaboration among scientists from the U.S. and Germany.
Chemical cocktail creates new avenues for muscle stem cell therapies
The advance could be a step toward the development of treatments for muscle loss or damage due to injury, age or disease.