genetics

Research brief: Scientists have identified hundreds of chemical modifications that can alter RNA’s protein-making instructions without affecting the core DNA.

By better understanding the dynamics of a key immune signaling molecule, scientists may be able to ‘hack’ the immune system to strengthen it.

The advance, researchers say, is like the cellular equivalent of discovering the Rosetta stone and may eventually lead to new treatments for diseases.

The treatment, developed by researchers from UCLA and the U.K., has restored immune function in more than 95% of patients in three clinical trials.

UCLA researchers and colleagues hope their first-of-its-kind catalog will reveal new targets for genetic and cell therapies for the disease.

The research, conducted on mice, targets a newly discovered molecular “checkpoint” that enables cancer stem cells to evade the immune system.

Research brief: A UCLA team has demonstrated that altering a key molecule used in the therapy yields superior and longer-lasting results in mouse models.

The project is the first to use the Nobel prize–winning technology to directly correct sickle mutation in blood stem cells.

Research brief: An approach pioneered at UCLA predicts which methicillin-resistant Staphylococcus aureus infections are likely to be cured with antibiotic therapy.

The Ginsburg Center builds on teamwork among scientists and physicians to advance research, enhance patient care for genetic conditions.

By identifying the underlying factors leading to bone loss and osteoporosis, UCLA dentist-scientists hope to pave the way to new treatments.

The first study to report genome-wide data on the prehistoric canid puts to bed a mystery biologists have pondered for more than 100 years.

UCLA astrophysicist Andrea Ghez and UC Berkeley biochemist Jennifer Doudna, both 2020 Nobel laureates, will be joined by climate change expert Emily A. Carter.

A massive unintended experiment in animal conservation taking place southeast of Las Vegas revealed an unexpected result.

The scientists were brought together by their shared belief that genetics could be a key to finding better approaches to the pandemic.

Research brief: Even successfully treated HIV-infected adults are at increased of many diseases more commonly associated with aging.

Research brief: The new screening method looks for particular bits of DNA that have been shed by the placenta and entered the mother's blood.

Spanning medicine, math and nanomaterials, support for campus scientific studies has grown almost 40% in five years.

In pregnant mice, the maternal gut microbiata plays a key role in regulating which genes are activated in the growing brain, UCLA biologists say.

Research brief: UCLA scientists have discovered that histones act as an enzyme that converts copper into a usable form for cells.

Researchers will focus on an immunotherapy known as CAR T, which uses genetically modified stem cells to target and destroy the virus.

Research brief: Findings from a UCLA study indicate some men may not require the intensive treatment they have traditionally received.

The blood cells, part of the body's first line of defense against infection, have been notoriously difficult to genetically engineer.

The findings are critical for researchers aiming to develop muscle stem cells in the lab that can be used to combat disease.

“We hope our method could be used in the future to prepare treatments that can be performed at the patient’s bedside,” said UCLA’s Paul Weiss.